Prof. Kazuhide Inoue
Education & Career History
1969-1973 Undergraduate School of Pharmaceutical Sciences, Kyushu University 1973-1975 Graduate School of Pharmaceutical Sciences, Kyushu University 1978-2005 Researcher, National Institute of Health Sciences 1985-1987 NIH, USA, a visiting fellow 1991-1992 University College London (Prof. G Burnstock), an honorary research fellow 2000-present Professor, Graduate School of Pharmaceutical Sciences, Kyushu University 2002-2005 Head, Division of Biosignaling, National Institute of Health Sciences
Awards (main)
1. 2007; Science Technology Award from the Minister of Education, Culture, Sports, Science and Technology-Japan
2. 2007, 2008, 2009, 2010, 2011; Award from Kyushu University for High Research Activity
3. 2010; The 3rd Setsuro Ebashi Prize of Japanese Pharmacology Society
4. 2013; The Pharmaceutical Society of Japan Award
Main academic activities
1. The Japanese Pharmacological Society (Council 1988-, Trustee 2010-)
2. The Japanese Society for Neurochemistry (Council 1991-, Trustee 2003-2013, President 2011-2013)
3. The Japanese Pain Society (Council 2002-, Trustee 2004-, President 2007-2008)
Main Editors
1. Purinergic Signalling (Associate Editor 2004―)
2. Molecular Pain (Editorial Board 200４－)
3. The Journal of Pharmacological Sciences (Associate Editors 2004-2006)
4. Molecular Brain (Editorial Board 2008－)
5. Advances in Pharmacological Sciences (Editorial Board 2008－)
6. The Open Pain Journal (Editorial Board 2008－)
7. The Open Clinical Chemistry Journal (Editorial Board 2008－)
Main Publications
1. M. Tsuda, Y. Shigemoto-Mogami, S. Koizumi, A. Mizokoshi､, S. Kohsaka, M. W. Salter and K. Inoue. P2X4 receptors induced in spinal microglia gate tactile allodynia after nerve injury. Nature 424, 778-783, 2003
2. J.A.M. Coull, S. Beggs, D. Boudreau, D. Boivin, M. Tsuda, K. Inoue, C.Gravel, M.W. Salter and Y. De Koninck. BDNF from microglia mediates the shift in neuronal anion gradient that underlies neuropathic pain. Nature, 438, 1017-1021, 2005
3. S. Koizumi, Y. Shigemoto-Mogami, K. Nasu-Tada, Y. Shinozaki, K. Ohsawa, M. Tsuda, B.V. Joshi, K.A. Jacobson, S. Kohsaka, K. Inoue. UDP acting at P2Y6 receptors is a mediator of microglial phagocytosis. Nature 446, 1091-1095, 2007
4. H. Tozaki-Saitoh, M. Tsuda, H. Miyata, K. Ueda, S. Kohsaka, K. Inoue. P2Y12 receptors in spinal microglia are required for neuropathic pain after peripheral nerve injury. J.Neurosci. 28:4949-56, 2008
5. M.Tsuda, T.Masuda, J.Kitano, H.Shimoyama, H.Tozaki-Saitoh, K.Inoue. IFN-γ receptor signaling mediates spinal microglia activation driving neuropathic pain. Pro.Natl.Acad.Sci.USA,106(19):8032-7,2009
6. M. Tsuda, Y. Kohro, T. Yano, T. Tsujikawa, J. Kitano, H. Tozaki-Saitoh, S. Koyanagi, S. Ohdo, R-R Ji, M. W. Salter, K. Inoue. JAK-STAT3 pathway regulates spinal astrocyte proliferation and neuropathic pain maintenance in rats. Brain 134(4): 1127-1139 (2011)
7. Biber K, Tsuda M, Saitoh-Tozaki H, Tsukamoto K, Toyomitsu E, Masuda T, Boddeke H, Inoue K. Neuronal CCL21 up-regulates microglia P2X4 expression and initiates neuropathic pain development. EMBO J 30:1864-73, 2011
8. M. Nishida, M. Ogushi, R. Suda, M. Toyotaka, S. Saiki, N. Kitajima, M. Nakaya, K.-M. Kim, T. Ide, Y. Sato, K. Inoue, and H. Kurose. Heterologous down-regulation of angiotensin type 1 receptors by purinergic P2Y2 receptor stimulation through S-nitrosylation of NF-κB, Pro.Natl.Acad.Sci.USA, 108(16):6662-7, 2011
9. T. Masuda, M. Tsuda, R. Yoshinaga, H. Tozaki-Saitoh, K. Ozato, T. Tamura, K. Inoue. IRF8 is a critical transcription factor for transforming microglia into a reactive phenotype. Cell Rep. 2012 Apr 19;1(4):334-40
10. M. Nakaya, M. Tajima, H. Kosako, A. Hashimoto, M. Ohba, S. Komiya, N. Tani, M. Nishida, H. Taniguchi, Y. Sato, M. Matsumoto, M. Tsuda, K. Inoue, and H.Kurose. GKR6-deficient mice exhibit reduced recycling of senescent red blood cells and impaired apoptotic cell clearance causing autoimmunity. Nature Communications. In press